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Study - High Fat or ‘Ketogenic’ Diet may Prevent, Reverse Heart Failure

Thursday, October 29, 2020

Research findings from Saint Louis University (SLU) showed high fat or “ketogenic” diets could completely prevent or may even reverse heart failure that is caused by metabolic process. The study, “Nutritional Modulation of Heart Failure in Mitochondrial Pyruvate Carrier-Deficient Mice,” was led by Kyle S. McCommis, Ph.D., assistant professor in Biochemistry and Molecular Biology at SLU.  Findings were published online last October 26 in Nature Metabolism. 

The team looked at a metabolic process that seems to be turned down in failing human hearts.  In an animal model, drastic heart failure in mice was bypassed by switching to high fat or “ketogenic” diets, which could completely prevent, or even reverse the heart failure. “Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure,” McCommis said.  

This research, which was initiated during McCommis’ postdoctoral and junior faculty positions at Washington University School of Medicine, then was completed at Saint Louis University School of Medicine. 

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